|
KMID : 0379520140300040277
|
|
한국독성학회지
2014 Volume.30 No. 4 p.277 ~ p.282
|
|
|
Immune Modulation of B. terrestris Worker (a Type of Bumblebee), Extract on CFA-induced Paw Edema in Rats
|
|
Ahn Mi-Young
Kim Soon-Ja
Han Jea-Woong
Yoon Hyung-Joo
Hwang Jae-Sam
Yun Eun-Young
|
|
|
Abstract
|
|
|
|
To develop a composition for enhancing immunity, based on alcohol extracts of the bumblebee as an active ingredient, bumblebee ethanol extracts were evaluated for their protective effect in chronic models of inflammation, adjuvant induced rat arthritis. B. terrestris worker extract (SDIEX) and, B. hypocrita sapporoensis lava an pupa extract (SPDYBEX), significantly decreased paw edema in arthritic rats, at a dose 100 mg/kg, respectively. The cytokine levels related inflammation of COX-2, sPLA2, VEGF, and TNF-α, were decreased, compared to positive control, indomethacin (5 mg/kg). Histopathological data demonstrated decreases inflammatory activity, hind paw edema, and repaired hyaline articular cartilage in DRG over a 2 wk administration. HPLC and GC-MS analysis of SDIEX and SPDYBEX revealed the presence of cantharidin.
|
|
|
KEYWORD
|
|
|
B. terrestris worker extract, B. hypocrita sapporoensis lava and pupa extract, Inflammation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|